Polymer processing often involves large deformations that align macromolecular chains in the amorphous phase, which makes the resulting material anisotropic and direction-dependent. Recent experimental studies at the Institut Charles Sadron focused on pre-oriented polycarbonate (PC), a high-performance transparent thermoplastic commonly used in applications such as eyeglass lenses and aircraft windscreens. In these experiments, samples were stretched up to a ratio of about 1.7 and then tested mechanically at different angles relative to the orientation direction. The results revealed contrasting behaviors: while yield stress and strain hardening increased with angle in compression, they decreased in tension. Moreover, indentation and scratch tests showed a preferential pile-up normal to the drawing direction, which appeared inconsistent with the bulk compressive response. These findings highlight a strong tension–compression asymmetry that is amplified by orientation, raising open questions about the multiscale origins of this behavior. Understanding the molecular level origin of the anisotropic response to indentation could lead to PC plastics with autonomous self-healing properties.