Internship and thesis proposals
Mechanical Characterization of cells: from Viscoelasticity to Membrane Rupture

Domaines
Biophysics
Soft matter
Physics of living systems

Type of internship
Expérimental
Description
This internship is part of an ANR-funded project on ultrasound-mediated drug delivery using microbubbles. Understanding how bubble cavitation induces transient membrane pores is crucial for optimizing therapeutic agent delivery across biological barriers. Despite its clinical promise, fundamental gaps remain in our understanding of cell membrane mechanics and rupture behavior under controlled mechanical stress. This project will use advanced micropipette-based techniques to quantify cell viscoelastic properties and membrane rupture thresholds under compression and tension, providing experimental data to validate computational models and optimize treatment parameters.

Contact
Julien Husson
Laboratory : LadHyX - UMR 7646
Team : Mécanique cellulaire
Team Website
/ Thesis :    Funding :