It has been recently recognized that every cell exhibits an electrical activity, from voltage drop across their membrane through patterning of surface charges. While the electrical activities of neurons and muscle cells have been widely documented with regards to their functions, the role of electric potentials in non-excitable cells remains to be explored. Several studies suggest that such bioelectricity could be fundamental for processes both at the unicellular and multicellular levels, such as development, cell migration, or cancer. In this internship, we propose to explore the intrinsic fluctuations of the bioelectric activity in cultured epithelial mammalian cells. We previously engineered cells to express a fluorescent biosensor reporting their electrical activity. On time scale of seconds to tens of minutes, significant fluctuations are observed that depend on the local context: isolated cells present large fluctuations, while islands of connected cells show dampened fluctuations. These fluctuations can be used to understand how cells are electrically coupled and how multicellular patterns of bioelectric activity emerge as well as better understand the biological and physical mechanisms dictating the electrical setpoint of cells. The intern will combine fluorescent live cell imaging and theoretical modeling to measure and model these fluctuations. Ideally, we are seeking for a student with a background in physics/math that is willing to perform experiments in biology.