Internship and thesis proposals
WearFLOW: a portable laser speckle imager for microcirculation dynamic monitoring

Domaines
Biophysics
Physics of liquids
Physics of living systems
Hydrodynamics/Turbulence/Fluid mechanics
Metrology

Type of internship
Expérimental
Description
We are offering an M1/M2 internship in the Biophotonics group at LCF to design a portable laser imager based on laser speckle contrast imaging (LSCI). LSCI maps 2D blood flow at high spatial and temporal resolutions. So far, clinical devices are bulky and must be handheld limiting their use. The goal of the internship is to overcome these limitations by making this modality portable and attachable to the patient's arm, avoiding constraints related to movement and facilitate measurements in real-world conditions, particularly during physical activity. The project involves methodological and scientific challenges : • Design and assemble a prototype incorporating optics and photonics components. • Develop test protocols on several microfluidic chips (custom made in the laboratory, without a clean room) simulating blood capillaries and surrounding tissue to evaluate the prototype ability to monitor microcirculation • Evaluate the impact of different hypotheses on light scattering in tissues on the biophysical models used to evaluate the microcirculation The skills you will be able to strengthen or acquire are : • Design and integration of photonic instruments. • Optical and electronic characterization of biomedical systems. • Experimental protocols on original microfluidic chips. • Teamwork in a multidisciplinary research environment. The internship may lead to a PhD, through application to already identified PhD grant funding opportunities.

Contact
Frederic PAIN
Laboratory : LCF - UMR8501
Team : Biophotonique
Team Website
/ Thesis :    Funding :