The in vitro detection of pathogenic markers, either proteins or nucleic acids, is crucial in numerous situations, e.g. early viral infections detection or efficient systemic disease diagnosis. We propose to development of optics based biomolecule detection tests using lanthanide-based nanoparticles (YVO4:Eu). Due to their remarkable optical and chemical properties and the development of efficient optical instrumentation, we plan to develop large-scale fast, portable, on-field compliant DNA/RNA detection tests, with unprecedented sensitivities. This internship will aim at developing biochemical, optical and analysis technologies to demonstrate the feasibility of this approach before a further integration into actual diagnostic tests, which may be implemented into medical contexts.