Internship and thesis proposals
Multiscale computational investigation of PAR-seeded condensates in DNA damage response

Domaines
Biophysics

Type of internship
Théorique, numérique
Description
This M2 project aims to understand the formation and structure of biomolecular condensates, which are crucial for DNA damage repair. Specifically, it will use multiscale simulations to investigate the interaction between PAR chains (nucleic acid scaffolds for these condensates) and the FUS protein, a key player in DNA repair. The project will be divided in two tasks: 1) Atomistic simulations with refined force fields to characterize PAR-FUS interactions in dilute solutions; 2) Coarse-grained simulations to explore the physical properties of PAR-FUS condensates under varying conditions. This internship should yield an improved molecular understanding of these crucial processes, with long term potential therapeutic impact as dysfunctional condensates are linked to diseases like cancer and neurodegenerative disorders

Contact
Elise Duboué-Dijon
Laboratory : LBT - UPR9080
Team : Laboratoire de Biochimie Théorique
Team Website
/ Thesis :    Funding :